EPA: More than just a “blood vessel cleaner”! What other benefits does it have?

Live a light and healthy life with a low fat content
According to statistics from The Lancet in 2023, the proportion of people in the world with sub-health has reached 82.8% . Sub-health is caused by physiological, psychological, social and unhealthy living habits. It is an intermediate state between health and disease, also known as the "third state of the body."
For those sub-healthy moments when you feel powerless, you can try to leave them to pure EPA .
01 "Ultra-pure": a lipid-lowering magic weapon for people with high TG
Dyslipidemia affects nearly half of the population and is becoming younger.
The "Guidelines for Blood Lipid Management in China (2023)" points out that with changes in dietary patterns, reduced physical activity and unhealthy lifestyles, the incidence of dyslipidemia in children and adolescents is as high as 20.3% to 28.5% .
A national survey in 2018 showed that 35.6% of adults have dyslipidemia, equivalent to 4 in 10 people. This has led to the mortality rate of cardiovascular and cerebrovascular diseases ranking first among all diseases.
In the long-term tug-of-war with high blood lipids, the two most critical indicators are cholesterol and triglycerides (TG) . Among them, low-density lipoprotein cholesterol (LDL-C) is the number one killer that causes atherosclerosis.
For people with high TG (excessive triglycerides), in addition to paying attention to LDL-C, it is more difficult to lower the TG index. Clinical studies have shown that EPA is effective in lowering triglyceride levels in the blood.
- Vascular Pharmacology 2017: Even with optimized statin therapy, some patients still have cardiovascular risks, and the auxiliary efficacy of EPA is widely recognized .
- EPA can effectively lower plasma triglycerides without affecting LDL-C, and has potential benefits for atherosclerotic plaques.
- 2020 "Guidelines for Primary Prevention of Cardiovascular Disease in China": If TG is still high after taking statins, large doses of high-concentration EPA preparations can be given to assist in lowering TG.
- Statins mainly target LDL-C and total cholesterol, and have limited effects on high TG , requiring auxiliary treatments such as EPA.
- "Current Opinion in Endocrinology, Diabetes, and Obesity" 2022: Highly purified, high-dose EPA has positive effects on patients with elevated TG at high cardiovascular risk.
Summary: For patients with hyperlipidemia and high triglycerides, combined with EPA has a better lipid-lowering effect.
02 A versatile combination of drugs
For people with sub-health conditions who need multiple protections, streamlining ingredients is more important than adding unnecessary ingredients . Pure EPA is highly compatible when used in combination with medications and is suitable for patients with chronic underlying diseases (such as those taking statins, hypoglycemic drugs, and anticoagulants at the same time).
- EPA has no inhibitory effect on the pharmacokinetics of rosiglitazone (a hypoglycemic drug), and its combined use is safe and well tolerated.
- EPA does not significantly change the anticoagulant pharmacodynamics of warfarin (an antithrombotic drug) during administration and is safe for healthy adults to take together.
The purer the EPA, the easier it is to combine with other drugs and the safer it is.
03 More than just a “blood vessel cleaner”: EPA’s multiple health benefits
- Joint health: EPA can effectively reduce joint inflammation, relieve the pain and stiffness of osteoarthritis, and help maintain bone density and reduce the risk of fractures.
- Protect eyesight: EPA and other Omega-3 fatty acids can slow down the progression of macular degeneration, and their antioxidant and anti-inflammatory effects protect the eyes and maintain good visual function.
- Pregnancy health: EPA reduces the risk of premature birth and promotes fetal brain and vision development. EPA in breast milk helps the cognitive development of newborns.
04 The neglected "emotion regulator"
In addition to physical sub-health, emotional sub-health should not be ignored. EPA has a positive impact on emotional regulation and mental health, which has been verified by many studies.
- Too little EPA in the diet can lead to neurological dysfunction. EPA can reduce the production of prostaglandins derived from arachidonic acid and help maintain brain-derived neurotrophic factor.
- EPA may optimize nerve cell function by reducing inflammatory mediators and improving cell membrane fluidity.
- EPA may also affect the uptake of tryptophan into the brain, thereby affecting the synthesis of serotonin (5-HT).
Clinical Application:
- ADHD: A 12-week controlled trial found that EPA supplementation can improve cognitive outcomes in adolescents with ADHD, especially those with low baseline EPA levels.
- Depression: EPA can increase brain serotonin and help relieve depression and anxiety. Omega-3 with high EPA content has an auxiliary therapeutic effect on mild to moderate depression.
- Cognitive function: A moderate amount of EPA can help improve memory, learning ability and overall cognitive function, and is particularly beneficial for the elderly to slow down cognitive decline.
In the countless moments when you are struck by sub-health, a high-purity EPA may be able to provide help to improve sudden helplessness, health problems, and daily mood swings.
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